TRPV1 and asthma: In a recent report, Cantero-Recasens et al.[5] have shown that a isoleucine-to-valine mutation at position 585 of the TRPV1 protein results in a 20-30% loss of channel function, and that the corresponding TRPV1 I585V (rs8065080) SNP is associated with a significantly lower risk of wheeze and cough in children with asthma.