TRPV4 dysfunction has already been associated to airway diseases: airway epithelial cells from cystic fibrosis patients show a defective regulation of TRPV4 [18,19], and SNPs in the TRPV4 gene have been found to be associated with chronic obstructive pulmonary disease (COPD) [20]. This evidence concerns the gene TRPV4 and cystic fibrosis.