Importantly, ETO homologue genes are involved in chromosomal translocations of acute leukemia, MTG16 in the generation of the AML1- MTG16 fusion gene of t(16;21) [13] in patients with therapy-induced leukemia, ETO in the generation of the AML1-ETO fusion gene of t(8;21) [14,15] and MTGR1 in the generation of AML1-MTGR1 fusion gene of t(20;21) [16]. Here, RUNX1 is linked to leukemia.