A significant association was found between the immunoreactivity of Rac1 and L-SIL (p = 0.02) and H-SIL (p = 0.005); RhoA and H-SIL (p = 0.03); Tiam1 and L-SIL (p < 0.001) and H-SIL (p < 0.001); and beta-Pix and H-SIL (p = 0.006). This evidence concerns the gene RAC1 and squamous cell intraepithelial neoplasia.