In conjunction with these studies we measured lung compliance (i.e., using FlexiVent) under both conditions of closed chest and open diaphragm and found that blocking CXCL12 resulted in improved lung compliance (Figure 7C and 7D) that was associated with markedly less ILD histopathology (Figure 7E and 7F). Here, CXCL12 is linked to interstitial lung disease.