Results from the multivariate analysis showed that the CD15+ TINs (p = 0.027), the depth of invasion (p = 0.041), the lymph node metastasis (p = 0.015) and the distance metastasis (p = 0.040) were independent prognostic factors of overall survival (Table 2). The gene discussed is FUT4; the disease is metastatic malignant neoplasm in the lymph nodes.