The effects of CF on leukocyte subsets in the lungs and BALF of asthmatic mice included changes in the number of Gr-1+/CD11b+ granulocytes and CD3-/CCR3+ eosinophils compared with the control group (Figure 4), and the decrease in CD3-/CCR3+ eosinophils was accompanied by concurrent decreases in eosinophils in the BALF (Figure 2). This evidence concerns the gene ITGAM and cystic fibrosis.