The primary objective of the REMOTUX trial (in vivo response monitoring of treatment with the EGFR-mAB cetuximab in metastatic colorectal cancer) is to evaluate the predictive relevance of the change in 18 F-FDG tumor uptake during short-term run-in treatment with cetuximab for the early clinical tumor response, determined according to the response evaluation criteria in solid tumors (RECIST) [12] after sequential Folfiri-cetuximab therapy. Here, EGFR is linked to neoplasm.