NHERF1 and neoplasm: In 13% of tumors, in addition to cytoplasmic NHERF1 immunoreactivity, NHERF1 showed also a plasma membrane localization; these overexpressing membranous NHERF1 tumors (13%) were significantly associated with tumor grade 2 (p = 0.037), positive PR status (p = 0.031), low MIB1 (p = 0.029) and with good NPI (p = 0.016).