The positive prognostic impact of membranous NHERF1 is in agreement with results obtained from our [17,18] and other laboratories [46], suggesting that NHERF1 might behave either as a tumor suppressor, when it is localized at the plasma membrane, or as an oncogenic protein, when it is shifted to the cytoplasm, depending on its subcellular distribution. This evidence concerns the gene NHERF1 and neoplasm.