Since, according to these results, the PVI+/membranous NHERF1- expression phenotype in grade 2 tumors is a poor prognosis factor, we have analyzed PVI/membranous NHERF1 immunophenotypes in a subgroup of patients stratified as having a family history of breast cancer, a category with high biological malignancy, as previously notified [1,19]. The gene discussed is NHERF1; the disease is breast cancer.