Furthermore, within SCCs, serum CAXII levels were significantly higher in patients with well- and moderately differentiated tumors than those with poorly differentiated ones (P = 0.027) (Fig. 4 A), and tended to be higher in patients with a tumor size of less than 3 cm rather than more than 3 cm (P = 0.0538). This evidence concerns the gene CA12 and neoplasm.