At present, some sero-diagnostic markers are used for lung cancer, such as carcinoembryonic antigen (CEA) and sialyl Lewis X antigen (SLX) for adenocarcinoma (AD), and cytokeratin 19 fragment (CYFRA) and squamous cell carcinoma antigen (SCCa) for squamous cell carcinoma (SCC) [3]. The gene discussed is CEACAM5; the disease is squamous cell carcinoma.