Several miR-143 targets, including DNMT3A and KRAS[32], [33], and miR-145 targets including BNIP3, IRS, C-MYC, YES and STAT1[34]–[36], have been identified, indicating that miR-143 and 145 act as tumor suppressors to repress tumor proliferation or promote apoptosis. This evidence concerns the gene IARS1 and neoplasm.