EBI3 and Autoimmunity: Formed by heterodimerization of Epstein-Barr virus-induced gene 3 (EBI3) protein with the IL-12 p35 subunit (IL-12A) [15], IL-35 inhibits inflammation in various autoimmunity models such as experimental colitis [16], [62], collagen-induced autoimmune arthritis [61], autoimmune demyelination in central nervous system [63], and type 2 T helper cell (Th2)-mediated allergic asthma [64].