BCL2 and brain ischemia: For instance, polysaccharides from Hyriopsis cumingii exhibited neuroprotective functions through anti-apoptotic and anti-oxidative activities in rat cerebral ischemia/reperfusion model [30]; Ganoderma lucidum polysaccharides could protect against rat cerebral ischemia by inhibiting apoptosis and the potential mechanisms may be associated with the modulation of Bcl-2 and caspase-3 pathway [31]; Cactus polysaccharides could reduce neuronal apoptosis and oxidative stress in rat cerebral ischemia as well [32].