In the central nervous system, CAR was regarded as a potential drug for Alzheimer's disease due to its inhibitory effect on acetylcholinesterase (AChE) activity by using phenolic hydroxyl group of CAR to bind to AChE and leading to a loss of function of AChE [14], [15], [16]. The gene discussed is ACHE; the disease is early-onset autosomal dominant Alzheimer disease.