Furthermore, because human LIM proteins are implicated in diseases as diverse as leukemia, epilepsy, cardiomyopathy, osteoporosis, and muscular dystrophy, understanding the evolutionary history of this superclass can help translational researchers with the identification of medically relevant sequence motifs, the determination of appropriate model species, and the proper association of findings from model systems to human homologs [11], [12], [13], [14], [85], [86]. Here, LPP is linked to epilepsy.