MFGE8 and systemic lupus erythematosus: Two common SNP were previously identified in the open reading frame of the MFGE8 gene called MFGE8 R3S (rs4945 for nucleotide C>A) and MFGE8 M76L (rs1878326 for nucleotide 226 A>C), associated with an increased risk of systemic lupus erythematosus [7].