Immunological cell and chemokine profile adjacent to squamous cell carcinoma was studied by immunohistochemical stain to assess the markers representative of T lymphocyte (CD3, CD4, CD8 and CD56), regulatory T cell (CD25, FOXP3) macrophage (CD68, iNOS) and related chemokine or chemokine receptor (IP-10 and CXCR3). This evidence concerns the gene CXCR3 and squamous cell carcinoma.