CSF3 and influenza: In 2011 the same group showed significant strain differences in disease severity (as measured by survival and body temperature), viral titres and cytokine and chemokine concentrations in the lungs of four inbred strains of mice (BALB/cByJ, C57BL/6J, A/J, and DBA/2J) but did not demonstrate any statistically significant genetic loci associated with influenza HK-X31 severity using a QTL approach, although suggestive statistical associations were reported for regions on three chromosomes (G-CSF chromosomes 5; CXCL10 chromosome 9, and IL-6 and CXCL1 on chromosome 18) [33].