Similar oligodendroglial abnormalities were also found in the FPC from subjects with major depressive disorder (MDD) [16], suggesting that cortical oligodendroglial abnormalities in the FPC, such as deficits in the proliferation and maturation of oligodendrocyte lineage (olig2(+)) cells, may represent a neuropathology common to various mood disorders. This evidence concerns the gene OLIG2 and major depressive disorder.