Using standard western blotting we confirmed increased TRPC3 protein expression in monocytes from both essential hypertensive patients and hypertensive patients with type 2 diabetes mellitus or metabolic syndrome compared to normotensive control subjects (1.30±0.07 for hypertensive patients, N = 8; 1.35±0.11 for hypertensive patients with type 2 diabetes mellitus or metabolic syndrome, N = 10; vs. 1.00±0.11 for normotensive control subjects, N = 8; p<0.05). Here, TRPC3 is linked to type 2 diabetes mellitus.