TRPC3 and essential hypertension: After siRNA knockdown of TRPC3, the TRPC3 expression was not significantly different in monocytes from patients with essential hypertension and normotensive control subjects (0.87±0.14 vs. 0.59±0.10; each n = 8, p>0.05), but there were no effects on TRPC3 expression after scrambled siRNA in monocytes from patients with essential hypertension or normotensive control subjects (Figure 3C).