TRPC3 and essential hypertension: Furthermore, after siRNA knockdown of TRPC3, the fMLP-induced migration was similar in monocytes from patients with essential hypertension and normotensive control subjects (23±3 vs. 17±4; each n = 8, p>0.05; Figure 3E) and there were no effects on monocytes migration after transfection with scrambled siRNA in monocytes from patients with essential hypertension or normotensive control subjects.