Furthermore, after siRNA knockdown of TRPC3, the fMLP-induced migration was similar in monocytes from patients with essential hypertension and normotensive control subjects (23±3 vs. 17±4; each n = 8, p>0.05; Figure 3E) and there were no effects on monocytes migration after transfection with scrambled siRNA in monocytes from patients with essential hypertension or normotensive control subjects. The gene discussed is TRPC3; the disease is hypertensive disorder.