On the other hand, the fMLP-induced migration of monocytes was significantly reduced in the presence of the tyrosine kinase blocker, genistein; or PI3K inhibitor, wortmannin; and an inhibitor of ERK, PD98059 (mean counts of migrated monocytes under magnification 40×; genistein 18±3, wortmannin 20±3, and PD98059 20±5 in monocytes from patients with essential hypertension; or genistein 19±1, wortmannin 20±2, and PD98059 20±3 in monocytes from normotensive control subjects; p<0.01 compared to their control conditions). This evidence concerns the gene FPR1 and essential hypertension.