Such a situation would be reminiscent of previously described pleiotropic effects on conformation of mutations in the gene encoding the calcium release channel (CRC) in pigs (causing malignant hyperthermia and porcine stress syndrome in homozygotes) [20] and in the MRC2 gene in cattle (causing Crooked Tail Syndrome in homozygotes) [4], [5]. This evidence concerns the gene MRC2 and Malignant hyperthermia.