The fact that Myc can stimulate angiogenesis independently of hypoxia-inducible factors [42]–[44] may account for the lack of impact on lymphomagenesis upon mutation of e.g. Ldha. Indeed, we show here that lymphomas from λ-Myc mice are very sensitive to hypoxia, most likely since they are Myc-driven and therefore rely on the TCA cycle and oxidative phosphorylation [45]. This evidence concerns the gene MYCL and lymphoma.