ACMSD and Parkinson disease: These analyses did not reveal genome-wide significant effect sizes for any additional locus, except ACMSD/TMEM163 (most significant SNP rs6723108, OR 0.91, P = 1.3×10−9, I2 = 46% [95% CI 0–73%], Figure S4, panel 1) and HLA (most significant SNP chr6:32609909, OR 0.78, P = 8.8×10−15, I2 = 84% [95% CI 70–91%], Figure S4, panel 2), both of which were reported to be associated with PD risk at genome-wide significance in previous work [16], [21].