While most loci in PDGene have only small effects on PD risk (with ORs ranging from 1.10 to 1.35, which are typical for complex diseases), for some loci much larger ORs were estimated (i.e. GBA [OR 3.51 in Caucasians], LRRK2 [OR 2.23 in Asians], and SYT11/RAB25 [OR 1.73 in Caucasians], see Table 2). Here, SYT11 is linked to Parkinson disease.