To begin to address which bacterial factors are important in V. parahaemolyticus-induced enteritis, we assessed colonization by and disease associated with a previously described set of isogenic V. parahaemolyticus mutants, each lacking one or more of the 3 principal described virulence factors: TDH (Δtdh), T3SS1 (ΔvscN1, an essential component of T3SS1) and T3SS2 (ΔvscN2, an essential component of T3SS2) [22]. The gene discussed is TDH; the disease is enteritis.