The cytokines interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 10 (IL-10) and tumor necrosis factor alpha (TNF alpha) and the serum proteins C-reactive protein (CRP), procalcitonin (PCT), S-100 and E-Selectin have been identified as a specific and accurate biomarker panel for the early diagnosis of sepsis. This evidence concerns the gene TNF and Sepsis.