Apart from insulin, glimepiride, a third generation sulfonylurea [15], pioglitazone, a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist, and a member of the thiazolidinedione family (TZD) [16], and metformin, a biguanide, are used for treatment of type 2 diabetes [9]. This evidence concerns the gene PPARG and type 2 diabetes mellitus.