In our meta-analysis, no statistically significant reverse association with gastric cancer was found either among H. pylori positive cancer patients compared with H. pylori negative controls or among H. pylori positive cancer patients compared with H. pylori positive controls (TT vs CT-plus-CC), but the p value in the former was approximate to 0.05, insinuating that IL-10-819 TT genotype may seem to be more protective from overall gastric cancer susceptibility in persons infected with H. pylori. This evidence concerns the gene IL10 and gastric cancer.