The ASXL1 gene can be translocated and fused to the PAX5 gene in acute lymphoblastoid leukemia [41] and altered by germ-line mutations in the Bohring-Opitz syndrome; this severe syndrome leads to death at an early age preventing to know whether susceptibility to hematopoietic diseases might result from ASXL1 germ-line mutations [42]. The gene discussed is ASXL1; the disease is Bohring-Opitz syndrome.