KRAS and lung adenocarcinoma: Furthermore, a reduction in cell viability was observed in EGFR wild-type cells by Yamanaka et al. [45] who studied the effect of an EGFR siRNA (5'-GUCAGCCUGAACAUAACAU-3'), in different set of lung adenocarcinoma cell lines harboring a spectrum of EGFR wild-type, mutant, and KRAS mutant cell lines (PC-9 [EGFR 15-bp exon 19 deletion]; H3255 [EGFR L858R]; HT-1 [wt EGFR and wt KRAS]; 11-18 [wt EGFR and wt KRAS]; LK87 [KRAS G12D]; A549 [KRAS G12S]).