SIRT1 and obesity due to melanocortin 4 receptor deficiency: Resveratrol was also shown to increase energy expenditure in mice [9, 10], through increased SIRT1 activation, and during conditions of high fat availability, resveratrol was capable of preventing diet-induced obesity and the onset of obesity-related metabolic diseases, so ultimately protecting mice against the lifespan curbing effects associated with high calorie intake.