HSPA8 and familial dilated cardiomyopathy: Wei et al. demonstrated significant up-regulation of cardiac and serum HSP71 in ICM and DCM [8] and they observed in cultured cardiomyocytes pretreated with hypoxia to mimic the in vivo conditions of the myocardium in response to myocardial damage, a significantly elevation of intracellular and extracellular HSP71.