AFP and cancer: On univariate analysis, PNI (P<0.05, Figure 1), presence of extrahepatic disease (P=0.05), portal vein thrombosis (P<0.05), AFP >400 (P<0.001), degree of intrahepatic spread (<0.001) and BCLC stage (P<0.01) were significant predictors of cancer-specific survival (Table 2).