PTGS2 and heart failure: A recent review of more than 36,000 prescriptions found an significantly increased cumulative risk over 12 months of cardiovascular events (myocardial infarction, stroke, hospitalisation for heart failure, coronary vascularisation and out of hospital cardiac death) for patients taking opioid analgesics compared to non-selective NSAIDs (p < 0.001) and to COX-2 inhibitors (p = 0.004) [21].