In this context it is perhaps noteworthy that in our earlier linkage-based positional cloning studies in Australian families where we reported the likely involvement of the activin type 2A receptor (ACVR2A) gene [24], [37] and the endoplasmic reticulum aminopeptidase 2 (ERAP2) gene [26] in risk of preeclampsia, we were also unable to replicate our gene-specific SNP associations in the same Norwegian case-control cohort as that used in this current study. Here, ACVR2A is linked to preeclampsia.