IL6 and Sepsis: Most importantly, the major result of this study is that after adjustment for usual clinical confounders (i.e. the presence of a severe head injury and an elevated SAPS II), the combinative test of adding the slope of mHLA-DR expression between days 3–4 and days 1–2 and early IL-6 concentration at days 1–2 was found to be independently associated with the risk of developing sepsis with a significant elevated OR (adjusted OR 18.4, 95%CI 4.9; 69.3, p = .00002).