IL6 and Sepsis: Interestingly, when slope of mHLA-DR expression at days 3–4 and IL-6 concentration at days 1–2 were expressed as a pair (both above their respective cut-off), after adjustment for other confounding factors, they appeared as the best predictor for developing sepsis, leading to an elevated adjusted OR at 18.4 (95% CI 4.9; 69.3, p = .00002) (Table 4).