We thoroughly studied Treg populations within each group, and observed higher significant proportions of FoxP3+ CD25- Treg compared to FoxP3+ CD25+ in HIV-TB and IRIS patients (Fig. 4A and B), whereas HIV, HIV-LTB individuals and HD showed significantly increased percentages of FoxP3+ CD25+ Treg compared to FoxP3+ CD25- cells (Fig. 4C, D and E). Here, FOXP3 is linked to Huntington disease.