BAX and central nervous system cancer: HA-14-1 and ABT-737, which are the most potent BH3 mimetic with high affinity (Ki ≤ 1) to Bcl-2, Bcl-xL, and Bcl-w, induce apoptosis in glioma cell lines by promoting the release of proapoptotic Bax from a Bax:Bcl-2 heterodimeric complex [40, 41].