BRCA1 and breast carcinoma: In fact, we recently performed immunohistochemical analysis of breast cancer tissue microarray (containing >300 aggressive breast cancer tumor samples) and discovered that compared to normal tissue, BRCA1-IRIS is overexpressed in the majority of these tumors, that expressed very low levels of AUF1 and pCBP2, high levels of cytoplasmic HuR and no BRCA1/p220 (ElShamy WM, unpublished data).