ACAN and neoplasm: When subcutaneously transplanted into nude mice, human OUMS-27 chondrosarcoma cells actively produce a cartilage-like matrix, including type II collagen and aggrecan, but have no capacity to produce ChM-I.(15) Instead, the cells secrete VEGF-A165 into the culture medium.(16) Thus, the cells form a vascularized but translucent tumor mass with cartilage-like ECM in nude mice.