Considering that unrecognized or covert brain infarcts and white matter lesions are linked to increased risk for stroke [15], we investigated if the NINJ2 A/A or G/A genotype increased silent cerebrovascular lesions such as leukoaraiosis, asymptomatic lacunes, or microbleeds prior to the manifestation of first strokes. Here, NINJ2 is linked to Abnormal cerebral white matter morphology.