NINJ2 and stroke disorder: When the extent of leukoaraiosis and onset age of stroke, two parameters that could have potential links with the NINJ2 SNP or post-stroke prognosis, were additionally entered into the multivariable analysis model to predict mRS at 1 year (Model I of Table 4), the SNP lost significance whereas the age was a statistically significant predictor and the leukoaraiosis burden was a marginally significant predictor for the follow-up mRS (Model II of table 4).