Taken together, these led us to reason that clinical implications for the NINJ2 SNP, including a potential effect on the onset age of the first-ever ischemic stroke, need to be further elucidated 'within a carefully characterized stroke population' in a detailed manner that includes quantitative analyses of magnetic resonance (MR) images, by which many of diagnostic and therapeutic decisions are today guided in clinic. Here, NINJ2 is linked to stroke disorder.