Special traits of MET and BC cell differentiation - such as decreased expression of vimentin and N-cadherin; downmodulation of molecules critically involved in tumor progression, such as galectin-3 and milk fat globule-epidermal growth factor 8 (MFG-E8); and production of β-casein - were detected in D609-treated MDA-MB-231 cells, together with long-standing and irreversible reduction of in vitro cell motility and invasion capabilities. Here, MFGE8 is linked to breast cancer.