Herein, we show that modified and chimeric forms of the Sm-TSP-2 vaccine antigen are also protective, even when formulated with a human-approved adjuvant combination, and that a schistosomiasis vaccine based on Sm-TSP-2 (or Sm-TSP-2/5B) satisfies additional selection criteria for progression into clinical trials, such as safety concerns around the potentially deleterious effects of pre-existing IgE responses in helminth endemic populations [1], [19]. The gene discussed is THBS2; the disease is schistosomiasis.