We found that 10 of these were significantly increased in colitis tissues in acute colitis (7-day model), namely IFN-γ, TNF-α, IL-1β, IL-6, IL-10, IL-17, MIP-1α, KC, MCP-1, and MIP-1β, demonstrating a mixed picture of Th1/Th17 cytokines plus pro-inflammatory chemokines; when assessed in serum, 6 of these were also increased, specifically IFN-γ, TNF-α, IL-1β, IL-6, KC and MCP-1, suggesting a Th1 bias, and a systemic pro-inflammatory effect (data not shown). This evidence concerns the gene TNF and colitis.