CDKN2A and open-angle glaucoma: Since the POAG variants were also identified in CDKN2B-AS1, the variants would probably affect the expression level of the downstream genes CDKN2A and CDKN2B. In fact, Burdon et al. reported up-regulated CDKN2A and CDKN2B expression in response to the elevated IOP [14], suggesting the involvement of the locus in molecular pathways leading to glaucoma development.