Although we need to confirm the above results using a larger HPG cohort, these results suggested that the significant SNPs identified in CDKN2B-AS1 on the 9p21.3 locus probably serve as genetic markers of glaucoma, which could be useful for investigating the etiology of glaucoma with respect to the vulnerability of the optic nerve to IOP. This evidence concerns the gene CDKN2B and glaucoma.