Apart from the regulatory role of γδ T cells in T1D [27], [28] CD4+CD62L+ T cells have been shown to inhibit development of the disease in NOD mice [59], [60] Here we show a decreased proportion of CD4+CD62L+ T cells in PP and a similar tendency in PLN of BALB/c mice fed the gluten-containing STD diet compared to the GF diet. This evidence concerns the gene CD4 and type 1 diabetes mellitus.