Further supporting this, a significant proportion of activated hepatic T cells, based upon expression of CD69 and CD44hi, were present in both RENCA-tumor and non-tumor bearing mice and high levels of IFNγ were detected in the supernatants of hepatic T cell from RENCA tumor-bearing mice co-cultured with RENCA cells compared splenic T cells under similar conditions. This evidence concerns the gene CD69 and neoplasm.