Focusing on the role of GnT-III as an important metastases suppressor, Yoshimura et al. have demonstrated that GnT-III gene transfected into B16 mouse melanoma cells with high metastatic capacity led to a suppression in the formation of β1,6 GlcNAc branching structures catalyzed by GnT-V, together with a significant decrease in lung colonization after mice intravenous administration of GnT-III transfectants [11]. Here, MGAT3 is linked to melanoma.