IGF2BP2 and diabetes mellitus: Although it has not been conclusively established that polymorphisms within the Igf2bp2 gene affect diabetes susceptibility through changes in the activity of IGF2BP2 protein per se [26], it is highly plausible that IGF2BP2 might influence the development and/or function of the pancreas or adipose tissue through effects on the expression of IGF2 or other proteins [14].