However, each of the IGF2BPs has been independently identified in other contexts (reviewed in [5], [6]): IGF2BP1 is orthologous to chicken ZBP-1 and mouse CRD-BP, which have been implicated in sorting β-actin mRNA and stabilizing c-myc mRNA respectively; IGF2BP2 is a splice variant of a p62 protein identified as an autoantigen in hepatocellular carcinoma; IGF2BP3 is identical to the KOC protein over-expressed in pancreatic cancer, and orthologous to Xenopus Vg1-RBP implicated in mRNA trafficking. The gene discussed is IGF2BP2; the disease is familial pancreatic carcinoma.