Liver responses detected in infected animals at 3 DPI overlapped many targets associated with acute colitis and disease severity including MCP-1, MIP-1α, MIP-1β, RANTES, and KC and neutrophil/Th17-related targets such as KC, IL-1β, IL-6, IL-12/23p40, and G-CSF. The gene discussed is IL6; the disease is colitis.