IGFBP3 and cancer: Due to their association with extracellular matrix (ECM) homeostasis, regulation of angiogenesis and cancer progression and metastasis [31]–[35], the expression of matrilin 2, CXCL10, and IGFBP3 mRNA was further analyzed by qPCR in seven cutaneous SCC cell lines, including one KGFR negative cell line (UT-SCC-111), HaCaT cells and normal epidermal keratinocytes treated with rKGF (10 ng/ml) for 24 h.