In addition to the critical role that β-catenin plays in prenatal melanocyte biology, we recently demonstrated a physical interaction between CREB and β-catenin following PKA/cAMP pathway activation in normal human melanocytes and B16-F0 mouse melanoma cells that led to a functional cooperation of β-catenin and CREB on the Mitf promoter [15]. This evidence concerns the gene MITF and melanoma.